Important: Compounded semaglutide and tirzepatide are not approved finished drug products. Pricing and availability are subject to clinical appropriateness and regulatory change. Prescriptions are issued only when an independent licensed medical provider determines individual clinical appropriateness. Read full consent →

Compounded semaglutide starting at $249/month and tirzepatide starting at $339/month through Open Water Rx. Each plan covers clinician review, medication if prescribed, shipping if prescribed, and ongoing support. No separate medication charge. Start your GLP-1 weight loss online in Florida or compare semaglutide vs tirzepatide.
Semaglutide
$249/mo
Clinician review + Rx if prescribed + shipping if prescribed
Tirzepatide
$339/mo
Clinician review + Rx if prescribed + shipping if prescribed
No commitment required · No insurance required · Discreet · Delivered to your door
All-Inclusive Pricing
Every Open Water Rx plan covers the same core items. The price you see is the price you pay. No separate medication charge, no shipping fee if prescribed, no consultation fee. Start your GLP-1 weight loss online in Florida or compare semaglutide vs tirzepatide.
Provider review
A licensed medical provider reviews your case after submission.
Prescription if approved
Personalized prescription issued through a licensed compounding pharmacy.
Shipping included if prescribed
If medication is prescribed, it ships directly to your address at no extra charge. Shipping timelines vary by program, pharmacy, and location.
Ongoing async follow-up
30-day review after initial prescription, then monthly async follow-up until steady-state dosing, then quarterly. Secure provider messaging throughout.
Base labs when appropriate
Baseline lab work included when clinically appropriate at your provider's discretion.
Transparent pricing
No setup fee, no consultation fee, no cancellation fee. Cancel anytime. Refunds are not available for a month once medication for that month has already been ordered.
Save up to $1,000+ per month vs. retail pharmacy pricing
Brand-name GLP-1 medications may cost significantly more without insurance. Open Water Rx offers clinician-guided access to compounded treatment options only when a licensed provider determines there is an individual clinical need. Compounded semaglutide starts at $249/month, covering clinician review, medication if prescribed, and shipping if prescribed.
$1,000+
Saved per month
vs. retail Wegovy®
Cost Comparison
Retail pharmacy prices are based on publicly available information as of early 2026 without insurance. Individual costs may vary.
| Option | Monthly Cost |
|---|---|
Compounded Semaglutide (Open Water Rx) Open Water Rx | $249 |
Compounded Tirzepatide (Open Water Rx) Open Water Rx | $339 |
Wegovy® (retail pharmacy, no insurance) | ~$1,300 |
Ozempic® (retail pharmacy, no insurance) | ~$900 |
Zepbound (retail pharmacy, no insurance) | ~$1,000 |
National telehealth platform (typical) | $350 to $500+ |
Retail pharmacy prices are approximate and based on publicly available information as of early 2026 without insurance. Compounded semaglutide and tirzepatide are not approved finished drug products. Individual costs may vary. GLP-1 medications have shown substantial weight loss in published clinical studies. Individual eligibility, treatment, and results vary.
Understanding GLP-1 Pricing
The significant price difference between compounded semaglutide and brand-name products like Wegovy or Ozempic reflects fundamentally different business models, not different active ingredients. Compounded semaglutide uses the same base active pharmaceutical ingredient (API) — semaglutide — as the FDA-approved brand-name products. The cost savings come from the absence of brand-name research and development amortization, multi-billion dollar marketing budgets, proprietary delivery device patents, and pharmaceutical company profit margins that are built into retail pricing.
Brand-name Wegovy costs approximately $1,349 per month at retail pharmacy pricing without insurance. Ozempic, though primarily approved for type 2 diabetes, is frequently prescribed off-label for weight loss at approximately $936 per month without insurance. Zepbound (tirzepatide) retails at approximately $1,060 per month. These prices reflect the enormous investment pharmaceutical companies made in clinical trials, FDA approval processes, and nationwide marketing campaigns — costs that are ultimately passed to patients regardless of insurance status.
Compounded medications, by contrast, are prepared by independent, licensed, FDA-registered compounding pharmacies for individual patients when a licensed medical provider determines there is a valid clinical need. The compounding process uses the same semaglutide or tirzepatide API but packages it in a simpler delivery system, avoiding the patented auto-injector devices that add hundreds of dollars to brand-name pricing. This is not a lesser product — it is the same medication delivered through a different, more cost-effective mechanism.
Open Water Rx's pricing of $249 per month for compounded semaglutide and $339 per month for compounded tirzepatide covers the entire care pathway: independent licensed clinician review, personalized prescription if clinically appropriate, discreet shipping if prescribed, and ongoing async provider support. There are no separate consultation fees, no shipping surcharges, and no hidden medication costs. This all-inclusive model is designed to make clinically-effective GLP-1 therapy accessible to patients who cannot afford or choose not to use brand-name medications, while maintaining the same standard of medical oversight.
Important: Compounded semaglutide and tirzepatide are not FDA-approved finished drug products and are not interchangeable with any commercially approved product. They are prescribed only when an independent licensed medical provider determines there is a valid individual clinical reason, not simply as a lower-cost alternative. Individual results vary and are not guaranteed. Pricing and availability are subject to clinical appropriateness and regulatory change.
Medication Options
Semaglutide and tirzepatide are presented as medication options, not service tiers. Your licensed clinician recommends the right fit based on your individual health profile. Pricing shown is the starting monthly rate.
Injectable Semaglutide
Prepaid plans may lower the effective monthly rate
No commitment required.
Injectable Tirzepatide
Prepaid plans may lower the effective monthly rate
No commitment required.
FAQ
Everything you need to know about the cost of semaglutide and tirzepatide in Florida in 2026.
Through Open Water Rx, compounded semaglutide starts at $249/month. This price covers clinician review, compounded semaglutide if prescribed, shipping if prescribed, and ongoing async support. No separate medication charge. Some longer-term prepaid plans may lower the effective monthly rate.
Through Open Water Rx, compounded tirzepatide starts at $339/month. This price covers clinician review, compounded tirzepatide if prescribed, shipping if prescribed, and ongoing async support. No separate medication charge. Some longer-term prepaid plans may lower the effective monthly rate.
Retail Wegovy® costs approximately $1,300/month and Ozempic® approximately $900/month without insurance. Compounded semaglutide is prepared by independent, licensed compounding pharmacies using the base active pharmaceutical ingredient (API), which is significantly less expensive than the branded finished drug product. The cost difference reflects the absence of brand-name markup, not a difference in the active ingredient itself. Compounded semaglutide is not an approved finished drug product and is not the same as or interchangeable with any commercially approved product.
Most insurance plans do not cover GLP-1 medications prescribed solely for weight loss. Coverage for type 2 diabetes indications varies by plan. Open Water Rx does not accept insurance. Pricing is clear from the start: semaglutide starting at $249/month, tirzepatide starting at $339/month. No prior authorizations, no insurance battles.
Both plans include: clinician review by a licensed medical provider, compounded medication if prescribed, shipping if prescribed, and ongoing async support including secure patient messaging. No separate medication charge. Pricing is clear from the start with no hidden fees.
Open Water Rx offers some of the most competitive pricing for clinician-guided GLP-1 therapy in Florida. Some online platforms advertise lower prices but charge separately for provider consultations, shipping, or medication. Always compare total monthly cost, not just the advertised plan fee. Our $249 and $339 starting prices cover clinician review, medication if prescribed, and shipping if prescribed. No separate charges.
Yes. Some longer-term prepaid plans may lower the effective monthly rate compared to month-to-month pricing. Details are provided during the enrollment process. There is no obligation to commit to a longer plan.
No. There is no separate consultation fee, setup fee, or enrollment fee. The monthly plan price covers clinician review, medication if prescribed, and shipping if prescribed. If a prescription is not issued following your evaluation, a refund may be considered on a case-by-case basis at our discretion. Contact members@openwaterrx.com within 7 days of the charge.
Open Water Rx pricing is competitive with or lower than major national GLP-1 telehealth platforms, with the added benefit of licensed medical providers, shipping included in the plan price if prescribed, and direct provider access. National platforms may charge separately for consultations, shipping, or medication. Always compare total all-in monthly cost.
Compounding availability is subject to FDA shortage status and regulatory change. If the FDA removes a drug from the shortage list, compounding of that drug may become subject to additional restrictions. Open Water Rx will make reasonable efforts to notify affected patients of any such changes. Pricing and availability are always subject to clinical appropriateness and regulatory change.
Related pages
Semaglutide in Florida
Full guide to compounded semaglutide: how it works, eligibility, and how to get a prescription online.
Tirzepatide in Florida
Full guide to compounded tirzepatide: dual GIP/GLP-1 mechanism, 20 to 22% avg weight loss, from $339/mo.
Semaglutide vs Tirzepatide
Side-by-side comparison of both medications: efficacy, cost, side effects, and who each is best for.
In 2026, compounded semaglutide through Open Water Rx starts at $249/month, covering clinician review, medication if prescribed, shipping if prescribed, and ongoing async support. No separate provider fee, no separate shipping charge, no hidden costs. Compounded tirzepatide starts at $339/month on the same basis. Both starting prices are significantly lower than retail pharmacy pricing for branded GLP-1 medications: Wegovy® runs approximately $1,300/month and Zepbound® approximately $1,000/month without insurance. Start your GLP-1 weight loss online in Florida or compare semaglutide vs tirzepatide.
The cost difference between compounded and branded GLP-1 medications reflects the absence of brand-name markup, not a difference in the active pharmaceutical ingredient. Compounded semaglutide and tirzepatide are prepared by licensed, FDA-registered compounding pharmacies and are available only by prescription from a licensed medical provider.
Open Water Rx is a telehealth platform connecting patients with independent licensed medical providers and licensed pharmacy partners. Prescriptions are issued only when a clinician determines individual clinical appropriateness. No insurance required. Discreet. Delivered to your door. No prior authorization. Availability varies by state.
Get started today. Semaglutide starting at $249/month, tirzepatide starting at $339/month. Clear pricing from the start. No commitment required.
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Compounded semaglutide and tirzepatide are not approved finished drug products. Pricing and availability are subject to clinical appropriateness and regulatory change.
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Semaglutide $249/mo · Tirzepatide $339/mo · No insurance required · Shipping included if prescribed
GLP-1 $249/mo · No insurance
Free to start · No hidden fees