Clinician-guidedweight losscare from home.

Everything. Licensed clinician review of your health evaluation, the prescription itself if your clinician determines treatment is clinically appropriate, compounded semaglutide from an FDA-registered pharmacy, shipping directly to your door, and ongoing clinician support throughout your treatment. One monthly price, no separate medication charge, no hidden fees. Tirzepatide plans start at $339/month and include the same.

No, and that is intentional. Every case is reviewed by an independent licensed medical provider who makes prescribing decisions based solely on your individual health profile. If treatment is not clinically appropriate for you, your clinician will explain why. We do not prescribe to everyone, and that standard is what makes the care meaningful.

In most cases, no. Open Water Rx is 100% telehealth. Your health evaluation, clinician review, prescription, and ongoing support all happen entirely online. Depending on your state's telehealth regulations, a brief live video visit with your clinician may be required before a prescription can be issued. If that applies to you, we will let you know clearly after your intake is submitted.

Semaglutide is a GLP-1 receptor agonist that activates a single pathway. In the STEP 1 trial (NEJM 2021), patients lost an average of 15–17% of body weight. Tirzepatide is a dual GIP/GLP-1 receptor agonist that activates two pathways simultaneously, producing greater average weight loss. In the SURMOUNT-1 trial (NEJM 2022), patients lost an average of 20–22% of body weight. Tirzepatide starts at $339/month vs $249/month for semaglutide. Your clinician will recommend the best fit based on your health profile.

Generally, adults with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related health condition such as type 2 diabetes, hypertension, or sleep apnea. You must be 18 or older. Final eligibility is determined by your independent licensed medical provider based on your complete individual health profile. GLP-1 therapy is not appropriate for everyone.

The compounded semaglutide and tirzepatide prescribed through Open Water Rx are prepared by independent, FDA-registered compounding pharmacies and are not FDA-approved finished drug products. They are not manufactured or sold by the makers of Ozempic®, Wegovy®, Mounjaro®, or Zepbound®. Compounded medications may differ from FDA-approved products in formulation, potency, and quality standards. Prescriptions are issued only when an independent licensed clinician determines individual clinical appropriateness.

Individual results vary. Most patients following clinical titration protocols begin noticing reduced appetite and early weight changes within the first 4–8 weeks. Meaningful weight loss typically builds over 3–6 months as dosing is titrated to an effective maintenance level. The clinical trial averages (15–22% body weight loss) were measured over 68–72 weeks. Results depend on adherence, diet, exercise, and individual metabolic factors.

Yes. You can cancel your subscription at any time by emailing members@openwaterrx.com, calling (941) 315-5217 Mon–Fri 9 AM–5 PM ET, or through your patient portal. Cancel before your renewal date to avoid the next charge. Refunds are not available for a month once medication for that month has already been ordered.